The Presidency announced the resignation of its chief operating officer Jessie Duarte late on Wednesday afternoon.

"She will leave her position at the end of May 2010 to pursue other interests and give more time to her political work for the African National Congress," the Presidency said in an official statement.
full story from M&G here
Reading the story, who'd want to be working in the Presidency at the moment

It's got to be pretty rough if Duarte's had enough.